Research Articles
BLASTp vs. Protein LLMs: Which Predicts Protein Function Better for Drug Discovery?
This article provides a comparative analysis for researchers and drug development professionals on the performance of traditional homology-based BLASTp searches versus novel protein Language Models (LLMs) for predicting protein function.
Choosing Your Microbial Workhorse: A Comprehensive Guide to E. coli BL21 vs K12 for Heterologous Protein Production
This article provides a detailed comparative analysis of the two most prevalent E.
Mastering B-Factors: The Essential Guide to Computational Protein Stability Engineering for Therapeutics
This comprehensive guide details the strategic application of B-factors (atomic displacement parameters) in protein engineering for enhanced stability, a critical requirement in biopharmaceutical development.
The B-FIT Method: A Comprehensive Guide to Enhancing Protein Thermostability for Drug Development
This article provides a complete analysis of the B-FIT (B-Factor Iterative Test) method for improving protein thermostability, a critical challenge in biotherapeutic development.
Decoding the Arms Race: How B Cell Receptors Co-Evolve with Viral Pathogens to Shape Immunity and Inform Vaccine Design
This article provides a comprehensive review for researchers and drug development professionals on the dynamic co-evolution between B cell receptors (BCRs) and viral pathogens.
Beyond pLDDT: A Critical Guide to AlphaFold's Confidence Scores for OOD Protein Sequence Validation
This article provides a comprehensive assessment of using AlphaFold's pLDDT scores for validating out-of-distribution (OOD) protein sequences.
Decoding the Protein Universe: A Comprehensive Guide to ESM2 and ProtBERT in Computational Biology
This article provides a thorough exploration of the cutting-edge protein language models, ESM2 and ProtBERT, and their transformative applications in computational biology.
Antibody-Specific vs. General Protein Models: A Performance Guide for AI-Driven Drug Discovery
This article provides a comprehensive analysis of antibody-specific artificial intelligence models versus general-purpose protein structure prediction tools.
Revolutionizing Biotherapeutics: How Antibody-Specific Language Models Are Accelerating Drug Design
This article provides a comprehensive guide to antibody-specific language models (AbsLMs) for researchers and drug development professionals.
Anfinsen's Dogma Revisited: How Protein Folding Principles Drive Modern Drug Discovery and Disease Research
This article provides a comprehensive exploration of Anfinsen's hypothesis on protein folding and its enduring impact on biomedical science.